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KMID : 1123920030170051299
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 5 p.1299 ~ p.1304
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Effect of Fructus Rubi on the isolated rat aorta
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Sun Sung-Kyu
Oh Kwang-Soo
Kim Nam-Sun
Soo Yeung-Hyung
Han Jong-Hyun
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Abstract
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This study is to determine the effect of Fructus Rubi to the phenylehrine (PE) induced contraction of isolated rat aorta. Contractile force was measured with force displacement transducer under 1.5g loading tension. Contractions evoked by PE 0.1 μM and KCI 65.4 mM were decreased significantly by Fructus Rubi. L-NNA, ODQ, indomethacin and atropine significantly altered the effect of Fructus Rubi, but propranolol did not change the relaxation of Fructus Rubi. These results indicate that Fructus Rubi can relax EP and KCI induced contraction of isolated rat aorta and that this decreasing contraction related to epithelium, nitric oxide, and parasympathetics.
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KEYWORD
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Contraction, relaxation, aorta, phenylehrine, Fructus Rubi
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